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KMID : 0854720100300010036
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Korean Journal of Asthma, Allergy and Clinical Immunology
2010 Volume.30 No. 1 p.36 ~ p.42
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The Effect of the Extracts of Taraxacum platycarpum (AF-343) in Atopic Dermatitis
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Kim Ji-Hyun
Lee Hye-In
Park Ju-Hee
Lim Yun-Young
Kim Beom-Joon
Lim In-Seok
Kim Myeung-Nam
Kim Hyun-Suck
Kim Jong-Keun
Han Sung-Hoon
Cho Soo-Muk
Kim Jae-Hyun
Park Ki-Moon
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Abstract
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Background: Taraxacum platycarpum has been investigated for its antiallergic activity in bronchial asthma, but few studies have been conducted to evaluate its efficacy for the treatment of atopic dermatitis (AD).
Objective: This study was designed to evaluate the efficacy of the extracts of Taraxacum platycarpum (AF-343) for the treatment of AD.
Method: Seventy-five patients with AD were randomly assigned either to a low-dose, high-dose or control groups. AF-343 and placebo were ingested for 8 weeks. The SCORing Atopic Dermatitis (SCORAD) scores, skin hydration, transepidermal water loss (TEWL), eosinophil, total IgE, eosinophil catinonic protein and cytokines were measured before and at the end of treatment.
Result: A significant reduction in the SCORAD scores at the end of treatment were observed in the control, low-dose and high-dose groups when compared with the initial scores (P=0.028, P＜0.001 and P＜0.001, respectively). High-dose treatment increased the skin hydration (P=0.013), but no significant change was observed in the low-dose and control groups (P=0.056 and P=0.624, respectively). The low-dose and high-dose treatment groups showed a significant reduction of TEWL from baseline (P=0.002 and P=0.031, respectively). High-dose treatment induced an increase in eotaxin and a decrease in IL-5 (P=0.021 and P=0.028, respectively).
Conclusion: These results show that AF-343 treatment can improve the severity and skin hydration in patients with mild AD.
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KEYWORD
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Taraxacum platycarpum, Atopic dermatitis
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